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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Systematic analysis of functional and structural changes after coronary microembolization: a cardiac magnetic
Frank Breuckmann1, Kai Nassenstein, Christina Bucher
1Department of Cardiology, West German Heart Center, Essen, Germany. Frank.Breuckmann@uk-essen.de
JACC. Cardiovascular Imaging
|April 10, 2009
Summary
Cardiac magnetic resonance (CMR) imaging effectively detects functional and structural changes from coronary microembolization (ME) in pigs. In vivo imaging shows increasing abnormalities, highlighting CMR
Area of Science:
- Cardiovascular Imaging
- Experimental Cardiology
- Diagnostic Techniques
Background:
- Coronary microembolization (ME) causes post-mortem edema and microinfarcts.
- Clinical detection of ME post-intervention correlates with worse prognosis.
Purpose of the Study:
- To detect morphological and functional effects of coronary microembolization (ME) in vivo.
- Utilize cardiac magnetic resonance (CMR) imaging in an established experimental animal model.
Main Methods:
- Coronary ME induced by intracoronary microsphere infusion in 18 minipigs.
- Repetitive in vivo CMR imaging (1.5-T) from 30 min to 8 hours post-ME.
- Ex vivo CMR imaging and histomorphology for correlation.
Main Results:
- Progressive wall motion abnormalities observed in vivo, reaching 100% by 8 hours.
- Myocardial edema detected by T2 imaging and late gadolinium enhancement (LGE) in vivo, increasing over time.
- Significant correlation between troponin I levels and in vivo/ex vivo LGE.
Conclusions:
- In vivo contrast-enhanced CMR imaging sensitively detects functional and structural myocardial changes after ME.
- Ex vivo LGE patterns differ from compact myocardial damage, suggesting need for improved spatial resolution.
- Enhanced spatial resolution in CMR is crucial for visualizing in vivo ME-induced structural alterations.
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