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Related Concept Videos

SNAREs and Membrane Fusion01:43

SNAREs and Membrane Fusion

Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
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Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
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Inhibitors Of Virion Release

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Subviral Agents

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Related Experiment Video

Updated: Jun 24, 2026

Method for Measurement of Viral Fusion Kinetics at the Single Particle Level
14:59

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Published on: September 7, 2009

Class III viral membrane fusion proteins.

Marija Backovic1, Theodore S Jardetzky

  • 1Department of Virology, Pasteur Institute, 25 rue du Dr. Roux, Paris, France. marija@pasteur.fr

Current Opinion in Structural Biology
|April 10, 2009
PubMed
Summary

Class III viral fusion proteins, including those from rhabdoviruses, herpesviruses, and baculoviruses, share structural similarities. Differences in their fusion loops and architecture may explain distinct cellular entry mechanisms.

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Area of Science:

  • Structural virology
  • Molecular biology
  • Membrane protein interactions

Background:

  • Viral fusion glycoproteins mediate membrane fusion for virus entry.
  • Structural studies have revealed conserved and divergent features among viral fusogens.
  • These proteins are classified into three distinct groups based on structural homology.

Purpose of the Study:

  • To review the characteristics of the newly identified class III viral fusion proteins.
  • To explore structural relationships and differences within this class.
  • To understand how structural variations relate to virus-specific cellular entry mechanisms.

Main Methods:

  • Review of accumulated structural data from viral fusion glycoproteins.
  • Comparative analysis of structural architectures and fusion loop features.
  • Integration of findings with existing knowledge of viral entry pathways.

Main Results:

  • Class III viral fusion proteins, including those from rhabdoviruses, herpesviruses, and baculoviruses, form a distinct structural class.
  • Despite shared structural relationships, class III proteins exhibit unique architectural features.
  • Distinctive membrane-interacting fusion loops are observed within class III proteins.

Conclusions:

  • Structural similarities and differences among class III viral fusion glycoproteins provide insights into viral entry.
  • Variations in fusion loop structure likely contribute to virus-specific cellular entry processes.
  • Further research on class III proteins can illuminate fundamental protein:membrane fusion mechanisms crucial for viral infection.