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Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry
Published on: March 5, 2019
[Acute immuno-allergic interstitial nephritis after treatment with fluindione. Seven cases]
Franck Reynaud1, Patrick Giraud, Jean-Marc Cisterne
1Centre hospitalier de Bigorre-Tarbes, service d'hémodialyse, boulevard de Maréchal-de-Lattre-de-Tassigny, 65013 Tarbes cedex 9, France. freynaud@ch-tarbes-vic.fr
Abstract:
We report seven cases of patients treated with fluindione, who presented with acute renal failure, associated with clinical features of allergy: poor status, fever, dyspnea, lymphadenopathy and erythroderma. All patients had elevated eosinophil counts. Renal biopsy disclosed in all cases a tubulo-interstitial nephritis with or without granuloma. The responsibility of fluindione, an oral anticoagulant widely used in France could be demonstrated. To our knowledge, there are only three reports of single cases of acute renal failure related to fluindione published so far to date. This serious side effect of fluindione should be recognized.
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