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Updated: Jun 24, 2026
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Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
Published on: October 13, 2023
Patients with IgA nephropathy exhibit high systemic PDGF-DD levels
Peter Boor1, Frank Eitner, Clemens D Cohen
1RWTH University of Aachen, Germany. boor@email.cz
Summary
Serum platelet-derived growth factor-DD (PDGF-DD) levels are elevated in IgA nephropathy (IgAN) patients, particularly those with early disease. These findings support PDGF-DD as a therapeutic target for mesangioproliferative glomerulonephritis.
Area of Science:
- Nephrology
- Immunology
- Molecular Biology
Background:
- Platelet-derived growth factor (PDGF) is a key mediator in mesangioproliferative glomerulonephritis (GN).
- Experimental GN models show significant increases in PDGF-DD serum levels, unlike PDGF-BB.
Purpose of the Study:
- To investigate serum PDGF-DD levels and intrarenal PDGF-DD mRNA expression in patients with various forms of GN.
- To assess the potential of PDGF-DD as a biomarker and therapeutic target in mesangioproliferative GN.
Main Methods:
- Assessed disease activity in 72 GN patients.
- Developed and utilized a novel PDGF-D ELISA to measure serum PDGF-DD levels.
- Studied renal PDGF-DD mRNA expression using RT-PCR.
Main Results:
- Serum PDGF-DD levels were significantly higher in IgA nephropathy (IgAN) patients compared to healthy controls.
- Lupus nephritis patients showed significantly lower PDGF-DD levels than controls.
- Intrarenal PDGF-DD mRNA expression did not differ between controls and patients, suggesting an extrarenal source.
Conclusions:
- Serum PDGF-DD levels are specifically elevated in IgAN patients, especially those with early-stage disease and preserved renal function.
- Elevated PDGF-DD in IgAN suggests it as a potential biomarker and supports the rationale for anti-PDGF-DD therapies.
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