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09:53
An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
Published on: August 25, 2017
Kaposi sarcoma after kidney transplantation
1Department of Nephrology, Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. einollahi@bmsu.ac.ir
Iranian Journal of Kidney Diseases
|April 10, 2009
Summary
Skin cancers, like Kaposi sarcoma (KS), are common in transplant patients. Replacing immunosuppressants with sirolimus may prevent KS by inhibiting its growth factors.
Area of Science:
- Oncology
- Immunology
- Transplantation Medicine
Background:
- Skin cancers are the most frequent tumors in immunosuppressed transplant recipients.
- Kaposi sarcoma (KS) is a prevalent malignancy in kidney transplant recipients, particularly in Iran.
- Human herpesvirus 8 (HHV-8) is associated with KS development.
Purpose of the Study:
- To investigate the role of sirolimus in the prevention of Kaposi sarcoma (KS) in transplant recipients.
- To explore sirolimus's antiangiogenic properties in relation to KS.
- To evaluate the potential of replacing calcineurin inhibitors with sirolimus.
Main Methods:
- Review of existing literature on KS in transplant recipients.
- Analysis of sirolimus's mechanism of action, including its antiangiogenic effects.
- Discussion of therapeutic strategies for KS, including immunosuppression modulation.
Main Results:
- Sirolimus demonstrates antiangiogenic activity by inhibiting vascular endothelial growth factor (VEGF) production and endothelial cell proliferation.
- KS regression is often observed upon reduction or withdrawal of immunosuppressive agents.
- Sirolimus's mechanism suggests potential for KS inhibition.
Conclusions:
- Sirolimus exhibits promising antiangiogenic properties that can inhibit KS progression.
- Switching from calcineurin inhibitors to sirolimus may offer a strategy for KS prevention in transplant recipients.
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