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Lamotrigine-induced aseptic meningitis: a case report

Michael A Green1, Mark N Abraham, Adam J Horn

  • 1Department of Family Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-8470, USA.

International Clinical Psychopharmacology
|April 10, 2009
PubMed

Insights

Aseptic meningitis, an inflammation of the meninges, is a rare side effect of lamotrigine. This report details the first case of lamotrigine-induced aseptic meningitis with a second episode upon rechallenge.

Area of Science:

  • Neurology
  • Pharmacology
  • Clinical Medicine

Background:

  • Aseptic meningitis presents with meningeal inflammation but negative bacterial cultures.
  • It mimics bacterial meningitis with fever, headache, and neck stiffness.
  • Drug-induced aseptic meningitis is an uncommon adverse effect linked to various medications.

Observation:

  • Lamotrigine is a known, though rare, cause of drug-induced aseptic meningitis.
  • Previous cases of lamotrigine-induced aseptic meningitis have been documented.
  • This study reports the fifth case of lamotrigine-induced aseptic meningitis.

Findings:

  • This case is unique as it describes a second episode of aseptic meningitis upon lamotrigine rechallenge.
  • The findings highlight the potential for recurrent lamotrigine-induced aseptic meningitis.

Implications:

  • Clinicians should consider lamotrigine as a potential cause of aseptic meningitis, especially with recurrent episodes.
  • Awareness of this rare side effect is crucial for accurate diagnosis and patient management.
  • Further research may elucidate the mechanisms behind lamotrigine-induced aseptic meningitis.

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