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Lamotrigine-induced aseptic meningitis: a case report.
Michael A Green1, Mark N Abraham, Adam J Horn
1Department of Family Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-8470, USA.
International Clinical Psychopharmacology
|April 10, 2009
Summary
Aseptic meningitis, an inflammation of the meninges, is a rare side effect of lamotrigine. This report details the first case of lamotrigine-induced aseptic meningitis with a second episode upon rechallenge.
Area of Science:
- Neurology
- Pharmacology
- Clinical Medicine
Background:
- Aseptic meningitis presents with meningeal inflammation but negative bacterial cultures.
- It mimics bacterial meningitis with fever, headache, and neck stiffness.
- Drug-induced aseptic meningitis is an uncommon adverse effect linked to various medications.
Observation:
- Lamotrigine is a known, though rare, cause of drug-induced aseptic meningitis.
- Previous cases of lamotrigine-induced aseptic meningitis have been documented.
- This study reports the fifth case of lamotrigine-induced aseptic meningitis.
Findings:
- This case is unique as it describes a second episode of aseptic meningitis upon lamotrigine rechallenge.
- The findings highlight the potential for recurrent lamotrigine-induced aseptic meningitis.
Implications:
- Clinicians should consider lamotrigine as a potential cause of aseptic meningitis, especially with recurrent episodes.
- Awareness of this rare side effect is crucial for accurate diagnosis and patient management.
- Further research may elucidate the mechanisms behind lamotrigine-induced aseptic meningitis.
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