Related Experiment Video

Updated: Jun 24, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

Cefazolin plasma protein binding saturability during pregnancy.

Karel Allegaert1, Tim Van Mieghem, Rene Verbesselt

  • 1Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Leuven, Belgium. karel.allegaert@uz.kuleuven.ac.be

Methods and Findings in Experimental and Clinical Pharmacology
|April 10, 2009
PubMed
Summary

This study found that pregnant individuals have a higher unbound fraction of cefazolin (CFZ) in their plasma compared to nonpregnant adults. Lower albumin levels during pregnancy likely explain this increased free cefazolin concentration.

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