Hand osteoarthritis in Chuvashian population: prevalence and determinants

Leonid Kalichman1, Eugene Kobyliansky

  • 1Department of Physical Therapy, Faculty of Health Sciences, Recanati School for Community Health Professions, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel. kalihman@zahav.net.il

Insights

Radiographic hand osteoarthritis (OA) is highly prevalent in older Chuvashians, particularly women with obesity. Moderate alcohol intake may offer a protective effect for women

Area of Science:

  • Rheumatology
  • Epidemiology
  • Public Health

Background:

  • Hand osteoarthritis (OA) is a common degenerative joint disease.
  • Understanding its prevalence and risk factors in diverse populations is crucial for public health initiatives.

Purpose of the Study:

  • To determine the prevalence of radiographic hand OA in a Chuvashian community sample.
  • To investigate associations between hand OA and age, sex, body mass index (BMI), smoking, and alcohol consumption.

Main Methods:

  • A community-based sample of 443 males and 384 females from the Chuvashian population was studied.
  • Radiographic evaluation of 14 hand joints per individual using the Kellgren and Lawrence grading scheme.
  • Statistical analyses included prevalence estimation, regression models, and chi-squared tests.

Main Results:

  • High prevalence of hand OA observed, with 89.2% of males and 97.6% of females over 65 years having at least one affected joint.
  • Obesity was associated with a nearly threefold increased risk of hand OA in females, but not in males.
  • No significant association was found between smoking and hand OA prevalence.
  • Moderate alcohol consumption demonstrated a protective effect on hand OA prevalence in women.

Conclusions:

  • Age is a significant factor in hand OA prevalence in the Chuvashian population.
  • Obesity is a key risk factor for hand OA in women, highlighting potential sex-specific differences in disease etiology.
  • Moderate alcohol consumption may have a protective role against hand OA in women, warranting further investigation.

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...