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Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS
Published on: April 13, 2016
Concentrations and correlations for eight metals in human liver
Guy E Griesmann1, Aeli C Hartmann, Fred F Farris
1Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
International Journal of Environmental Health Research
|April 10, 2009
Summary
This study measured eight metals in human livers, finding significant correlations between certain metal pairs like zinc-cadmium and iron-lead. Age was negatively correlated with copper levels in these human liver samples.
Area of Science:
- Human Toxicology
- Environmental Health
- Biometals Research
Background:
- Understanding metal accumulation in human organs is crucial for assessing health risks.
- Liver tissue is a key site for metal storage and detoxification.
- Previous research has explored metal concentrations, but inter-metal and age-related correlations require further investigation.
Purpose of the Study:
- To quantify concentrations of eight essential and toxic metals in human liver tissue.
- To explore correlations among these metal concentrations.
- To investigate the relationship between metal levels and subject age.
Main Methods:
- Autopsy liver specimens from 32 adult males were analyzed.
- Concentrations of calcium (Ca), cadmium (Cd), copper (Cu), iron (Fe), mercury (Hg), magnesium (Mg), lead (Pb), and zinc (Zn) were determined.
- Simple and multiple correlation analyses were performed on metal concentrations and subject age.
Main Results:
- Significant positive correlations were observed for zinc-cadmium, iron-lead, magnesium-mercury, and magnesium-zinc pairs.
- A negative correlation was found between age and copper levels.
- Multiple correlations indicated associations between magnesium with mercury and zinc, lead with iron and age, lead with iron and copper, and zinc with magnesium and cadmium.
Conclusions:
- The human liver exhibits complex interrelationships between various metal concentrations.
- Age influences copper levels, suggesting a potential biological or environmental interaction.
- Findings provide a basis for understanding metal homeostasis and toxicokinetics in the human liver.
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