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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Modeling thyroid cancer in the mouse.

X-G Zhu1, S-Y Cheng

  • 1Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|April 10, 2009
PubMed
Summary
This summary is machine-generated.

Thyroid cancer incidence is rising globally. This review highlights mouse models for studying thyroid cancer genetics and developing new therapies, focusing on follicular thyroid carcinomas.

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Area of Science:

  • Endocrinology
  • Oncology
  • Genetics

Background:

  • Thyroid carcinomas are the most common endocrine tumors, with increasing global incidence.
  • Four main types exist: papillary, follicular, anaplastic, and medullary.
  • Advances in identifying genetic alterations are notable, especially in papillary and medullary types.

Purpose of the Study:

  • To review existing mouse models for thyroid cancer.
  • To emphasize models relevant to follicular thyroid carcinomas.
  • To discuss challenges in developing new thyroid cancer models.

Main Methods:

  • Review of literature on established mouse models for thyroid cancer.
  • Focus on genetic alterations and molecular pathways.
  • Analysis of model utility for carcinogenesis research and therapeutic target identification.

Main Results:

  • Mouse models are crucial for understanding thyroid cancer development.
  • Specific models exist for papillary, follicular, and medullary thyroid carcinomas.
  • Progress has been made in modeling genetic alterations.

Conclusions:

  • Mouse models are invaluable for thyroid cancer research.
  • Further development is needed to address modeling challenges.
  • These models aid in identifying therapeutic targets.