Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromium-induced kidney disease.

R P Wedeen1, L F Qian

  • 1VA Medical Center, East Orange, NJ 07019.

Environmental Health Perspectives
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

While acute kidney injury from high chromium exposure is known, chronic kidney disease from long-term, low-level chromium exposure remains unproven. Further research is needed to assess potential persistent renal injury in chromium-exposed workers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Overexpression of miR-195-5p reduces osteoporosis through activating BMP-2/SMAD/Akt/RUNX2 pathway via targeting SMURF1.

Journal of biological regulators and homeostatic agents·2021
Same author

Expression of insulin-like growth factor II and its receptor in liver cells from patients with chronic liver diseases.

World journal of gastroenterology·2016
Same author

Lead poisoning: the evolving definition.

The international journal of occupational and environmental medicine·2012
Same author

Optimization of venous return tubing diameter for cardiopulmonary bypass.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2001
Same author

Lead and hypertension: who cares?

International journal of occupational and environmental health·2000
Same author

Consent in epidemiology: implications of history for public policy.

Archives of environmental health·2000

Area of Science:

  • Toxicology
  • Nephrology
  • Occupational Health

Background:

  • Kidney disease is a known risk of chromium exposure.
  • Acute tubular necrosis (ATN) from high chromate doses is documented in animal studies.
  • Low molecular weight (LMW) proteinuria in chromium workers suggests potential long-term kidney effects.

Purpose of the Study:

  • To review the evidence for chromium-induced kidney disease.
  • To assess the risk of chronic renal injury from occupational and environmental chromium exposure.
  • To highlight the need for further research on long-term, low-level chromium exposure effects.

Main Methods:

  • Review of existing literature on chromium toxicity and kidney disease.
  • Analysis of studies on acute tubular necrosis (ATN) in animals and humans.

Related Experiment Videos

  • Examination of reports on low molecular weight (LMW) proteinuria in chromium-exposed workers.

    • Main Results:

    • High-dose chromate exposure causes acute tubular necrosis (ATN) in proximal tubules.
    • Low molecular weight (LMW) proteinuria and increased beta 2-microglobulin excretion are observed in chromium workers.
    • LMW proteinuria is often reversible and not definitive evidence of chronic kidney disease.

    Conclusions:

    • Chromium-induced ATN and LMW proteinuria suggest potential for persistent renal injury from low-level, long-term exposure.
    • The absence of reported chronic renal disease does not equate to absence of risk.
    • Prospective studies are needed to evaluate delayed renal effects of chronic low-level chromium exposure.