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Updated: Jun 24, 2026
3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography
Published on: October 24, 2019
Three-dimensional localization of implanted biomaterials in anatomical and histological specimens using combined
Vincent M J I Cuijpers1, X Frank Walboomers, John A Jansen
1Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands .
Abstract:
For adequate histological processing of implanted biomaterials or tissue-engineered constructs, it is sometimes essential to obtain insight into the localization of structures inside the tissue samples. Observation of three-dimensional (3D) surface reconstruction, including basic photorealistic texture characteristics as surface pattern and color combined with X-ray computed tomography 3D reconstruction at different levels, is a useful approach to localize anatomical or implanted structures within experimental tissue samples. Because of the possible observation of structures of interest in a 3D environment, fusion of these techniques can greatly facilitate histological processing.
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