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Updated: Jun 24, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
Published on: September 27, 2024
Does statin usage reduce the risk of corticosteroid-related osteonecrosis in renal transplant population?
Muhammad Ajmal1, A J Matas, Michael Kuskowski
1Department of Orthopaedic Surgery, Veterans Affairs Hospital, Vanderbilt University, 1310 24th Avenue South, Nashville, TN 37212, USA.
Abstract:
The relationship between corticosteroids and osteonecrosis is well known. Limited data suggest that statins modulate cholesterol metabolism and may protect against osteonecrosis. The authors analyzed their prospective renal transplant database to determine if statin usage reduces the incidence of corticosteroid-related osteonecrosis and identified 2,881 renal transplantation patients who met the entry criteria. Among 338 patients on statins, 15 (4.4%) developed osteonecrosis, versus 180 of 2,543 (7%) patients who were not on statins. Osteonecrosis-free survival was similar in patients with and without statin exposure.
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