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Published on: December 17, 2019
CARD9 versus CARMA1 in innate and adaptive immunity
Hiromitsu Hara1, Takashi Saito
1Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. harah@cc.saga-u.ac.jp
Trends in Immunology
|April 11, 2009
Summary
Nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) signaling are regulated by CARD9 and CARMA1 adaptors. These molecules form complexes with BCL10-MALT1, controlling immune responses in innate and adaptive immunity.
Area of Science:
- Immunology
- Cellular Signaling
- Molecular Biology
Background:
- Nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) are key signaling pathways activated by immunoreceptors.
- B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue (MALT1) are essential for ITAM-mediated NF-kappaB and MAPK activation in immunity.
Purpose of the Study:
- To elucidate the roles of CARD-containing MAGUK protein 1 (CARMA1) and CARD9 in immune signaling.
- To describe cell-type-specific regulation mechanisms of NF-kappaB and MAPK activation by CARMA1 and CARD9.
Main Methods:
- Investigated the function of CARMA1 and CARD9 in immune cell signaling pathways.
- Analyzed the formation of complexes between CARD adaptors and BCL10-MALT1.
- Examined immune responses mediated by innate and adaptive immunoreceptors.
Main Results:
- CARMA1 and CARD9 act as crucial regulators in the ITAM-mediated signaling pathway.
- CARMA1 forms complexes with BCL10-MALT1 in lymphoid cells, while CARD9 does so in myeloid cells.
- These adaptors control NF-kappaB and MAPK activation through various immunoreceptors.
Conclusions:
- CARMA1 and CARD9 are critical adaptors linking ITAM-coupled receptors to NF-kappaB and MAPK activation.
- Understanding these pathways is vital for comprehending innate and adaptive immune responses.
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