Coma blisters in 2 children on anticonvulsant medication
Anna Basu1, Sara Brown, Nigel Kirkham
1Department of Paediatric Neurology, Newcastle General Hospital, Newcastle Upon Tyne, United Kingdom. a.p.basu@ncl.ac.uk
Journal of Child Neurology
|April 11, 2009
Summary
Coma blisters, characterized by skin blistering and sweat gland damage, can occur in sedated children. This study highlights a new association between coma blisters and anticonvulsant medications in pediatric patients.
Area of Science:
- Dermatology
- Neurology
- Pediatrics
Background:
- Coma blisters, involving eccrine sweat gland necrosis, are linked to impaired consciousness and were initially observed with barbiturate intoxication.
- The exact causes of coma blisters are complex and not solely attributable to pressure.
- With decreased barbiturate use, awareness of coma blisters may be declining, despite associations with newer medications.
Observation:
- This study reports two new cases of coma blisters in children receiving anticonvulsant medications.
- In one case, recurrent coma blisters appeared alongside obtundation and edema in a child.
Findings:
- Anticonvulsant medications represent a newly identified association with coma blister formation in children.
- Recurrent coma blisters can manifest in pediatric patients sedated with anticonvulsants.
Implications:
- Clinicians should be aware of the potential for coma blisters in children sedated with anticonvulsant drugs.
- Recognizing this association is crucial for accurate diagnosis and management of skin manifestations in sedated pediatric patients.
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