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Related Experiment Video

Updated: Jun 24, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Circulating calcitriol concentrations and total mortality.

Armin Zittermann¹, Stefanie S Schleithoff, Sabine Frisch

¹Department of Cardio-Thoracic Surgery, Heart Center North Rhine-Westfalia, Ruhr University Bochum, Bad Oeynhausen, Germany. azittermann@hdz-nrw.de

Clinical Chemistry

|April 11, 2009

Summary

This summary is machine-generated.

Low calcitriol levels predict higher midterm mortality in heart patients. This study highlights calcitriol

Related Experiment Videos

Last Updated: Jun 24, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Area of Science:

Cardiology
Endocrinology
Nutritional Science

Background:

Vitamin D supplementation is linked to reduced cardiovascular events and mortality.
The impact of low calcitriol, the active vitamin D hormone, on mortality remains unclear.
This study investigates calcitriol's predictive value for mortality in cardiac patients.

Purpose of the Study:

To determine if low calcitriol levels predict midterm mortality in patients at a specialized heart center.
To evaluate the association between calcitriol concentrations and various cardiovascular risk factors.

Main Methods:

Prospective cohort study of 510 patients from a specialized heart center.
Patients were stratified into quintiles based on circulating calcitriol concentrations.
Midterm mortality (up to 1 year) was assessed in relation to calcitriol levels.

Main Results:

Patients in the lowest calcitriol quintile had higher rates of heart failure, hypertension, diabetes, and renal failure.
The lowest calcitriol quintile showed significantly lower 1-year survival rates (66.7%) compared to the highest (96.1%).
A calcitriol cutoff of 25 ng/L best discriminated between survivors and nonsurvivors (AUC 0.72).

Conclusions:

Decreased calcitriol levels are associated with increased midterm mortality in patients treated at a specialized heart center.
Calcitriol levels may serve as a prognostic marker for mortality risk in cardiac populations.