Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multicompartment Models: Overview

Multicompartment Models: Overview

Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...

Modeling and Similitude

Modeling and Similitude

Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...

Typical Model Studies

Typical Model Studies

Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Primer PICKR: literature-mined scoring platform for robust RT-qPCR primers.

Nature communications·2026

Same author

NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer.

Nature communications·2026

Same author

Tissue tension fosters macrophage-driven lipid peroxidation-induced DNA damage.

Cancer cell·2026

Same author

The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer.

Cancers·2026

Same author

Inflammation drives TGFβ1 activation via the αvβ6 integrin-mechanotransduction pathway in human skin.

iScience·2026

Same author

Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment.

Cancer research·2026

Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026

Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026

Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026

Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026

Same journal

Retraction.

Science (New York, N.Y.)·2026

Same journal

Making time.

Science (New York, N.Y.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

Multiscale modeling of form and function.

Adam J Engler¹, Patrick O Humbert, Bernhard Wehrle-Haller

¹Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

Science (New York, N.Y.)

|April 11, 2009

Summary

This summary is machine-generated.

Tissue development relies on cell adhesion and molecular switches, with conserved modules guiding cell fate across multiple scales. These processes sculpt tissue structure, function, and homeostasis through emergent properties.

More Related Videos

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Related Experiment Videos

Last Updated: Jun 24, 2026

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Area of Science:

Developmental Biology
Cell Biology
Biophysics

Background:

Topobiology explains morphogenesis via differential cell adhesion.
This paradigm now incorporates force-dependent switches, tissue tension, and microenvironment interactions.
Tissue development involves conserved modules operating across molecular, subcellular, cellular, and tissue levels.

Purpose of the Study:

To discuss the origin of conserved decision-making modules in tissue development.
To illustrate how adhesion-directed multicellular structures shape tissue functionality and homeostasis.
To explore the role of emergent tissue properties in spatial organization and regulation.

Main Methods:

Literature review and theoretical discussion.
Analysis of molecular and cellular mechanisms.
Examination of emergent properties in multicellular systems.

Main Results:

Morphogenesis is driven by differential cell adhesion, modulated by force-dependent switches and microenvironmental cues.
Conserved decision-making modules regulate cell and tissue fate across multiple length scales.
Emergent properties of tissues, such as tension fields and energy optimization, are crucial for sculpting tissue structure and maintaining homeostasis.

Conclusions:

Tissue development is a multi-scale process governed by conserved modules integrating cell adhesion, mechanical forces, and signaling.
Adhesion-directed multicellular structures and emergent tissue properties are key to tissue sculpting, functionality, and homeostasis.
Understanding these principles provides insights into tissue development and potential therapeutic strategies.