Related Experiment Video

Updated: Jun 23, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Myocardial infarction in a patient with factor XI deficiency and a lupus anticoagulant

J E Humphries1, A E Schlein, I J Sarembock

  • 1Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908.

European Heart Journal
|September 1, 1991
PubMed

Insights

Myocardial infarction is rare in patients with Factor XI deficiency. This case highlights a patient with both Factor XI deficiency and antiphospholipid syndrome experiencing recurrent myocardial infarctions, prompting discussion on Factor XIa's role in fibrinolysis.

Area of Science:

  • Cardiology
  • Hematology
  • Thrombosis

Background:

  • Myocardial infarction (MI) is a serious cardiovascular event.
  • Antiphospholipid syndrome (APS) is associated with thromboembolic disorders.
  • Factor XI deficiency is a rare bleeding disorder.

Observation:

  • A 64-year-old male patient experienced two myocardial infarctions within three months.
  • The patient had co-existing Factor XI deficiency and lupus anticoagulant.

Findings:

  • This case presents a rare concurrence of myocardial infarction in a patient with Factor XI deficiency and antiphospholipid syndrome markers.
  • The study discusses the potential involvement of Factor XIa in fibrinolysis.

Implications:

  • Understanding the interplay between Factor XI deficiency, antiphospholipid syndrome, and myocardial infarction is crucial for risk assessment.
  • Further research into Factor XIa's role in fibrinolysis may reveal novel therapeutic targets for thrombotic disorders.

More Related Videos

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures10:01

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Published on: March 12, 2018

Extracellular Vesicle Tissue Factor Activity Assay03:53

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...