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Sevoflurane and isoflurane decrease TNF-alpha-induced gene expression in human monocytic THP-1 cells: potential role

Kim A Boost1, Tobias Leipold, Patrick Scheiermann

  • 1Klinik für Anästhesiologie der Ludwig-Maximilians-Universität München, Klinikum Grosshadern, D-81377 München, Germany. kim.boost@med.uni-muenchen.de

International Journal of Molecular Medicine
|April 11, 2009
PubMed
Summary

Volatile anesthetics like sevoflurane and isoflurane inhibit inflammatory responses by blocking the NF-kappaB pathway in human cells. This mechanism involves increased IkappaBalpha, reducing inflammatory cytokine release and NF-kappaB translocation.

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