Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 24, 2026

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling
07:11

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

External validation of the paediatric logistic organ dysfunction score.

Pedro Celiny R Garcia1, Pablo Eulmesekian, Ricardo G Branco

  • 1Hospital São Lucas da PUCRS, Rua Curupaiti 62, Porto Alegre, RS CEP 90820-090, Brazil. celiny@terra.com.br

Intensive Care Medicine
|April 11, 2009
PubMed
Summary

The paediatric logistic organ dysfunction (PELOD) score shows excellent discrimination in South American pediatric intensive care units (PICUs). However, it over-predicts mortality and has poor calibration, requiring careful use in clinical trials.

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRSA Septic Thrombophlebitis and Pulmonary Embolism: A Case Report Highlighting the Tight Bond With Infective Endocarditis.

Clinical case reports·2026
Same author

Acute Bronchiolitis, Pediatric Acute Respiratory Distress Syndrome, and Sepsis: Leading Journal Reads and What This Means.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

The editor replies.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Pediatric Critical Illness Investigation and Understanding Survival Biology.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Writing for Pediatric Critical Care Medicine: Using a Research Letter as an Option for Publication.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Connecting Clinical Practice Guidelines with Bundles, Implementation, and Quality Improvement Studies.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026

Area of Science:

  • Pediatric critical care medicine
  • Clinical scoring systems
  • Epidemiology of critical illness

Background:

  • The Paediatric Logistic Organ Dysfunction (PELOD) score is used to assess critically ill children.
  • Validation of existing clinical scores in diverse populations is crucial for their reliable application.
  • South American pediatric intensive care units (PICUs) require validated tools for patient management and research.

Purpose of the Study:

  • To externally validate the Paediatric Logistic Organ Dysfunction (PELOD) score in two South American PICUs.
  • To assess the discriminative ability and calibration of the PELOD score and its daily version (dPELOD).
  • To evaluate the PELOD score's utility as a surrogate endpoint in clinical trials.

Main Methods:

  • A prospective observational cohort study was conducted in PICUs in Brazil and Argentina.

Related Experiment Videos

Last Updated: Jun 24, 2026

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling
07:11

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

  • Data included demographics, diagnoses, interventions, length of stay, and mortality.
  • The PELOD and daily PELOD (dPELOD) scores were calculated using the worst daily values and worst overall PICU values, respectively.

    • Main Results:

    • A total of 1,476 admissions were analyzed, with observed mortality of 4.7% and predicted mortality of 6.6%.
    • The PELOD score demonstrated excellent discrimination (Area Under the ROC Curve = 0.93).
    • Both PELOD and dPELOD scores showed poor calibration (Hosmer-Lemeshow test) and over-predicted mortality, particularly in specific risk intervals.

    Conclusions:

    • The PELOD score is reproducible and exhibits excellent discriminative capacity in the studied South American PICUs.
    • The score over-predicts mortality and demonstrates poor calibration, potentially due to identified deficiencies.
    • Caution is advised when using the PELOD score as a surrogate endpoint in clinical trials due to its calibration issues.