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Matrix metalloproteinase-2 promoter variability in psoriasis
Vladimir Vasku1, Julie Bienertova Vasku, Veronika Slonková
11st Department of Dermatology, St. Ann's Faculty Hospital, Masaryk University Brno, Pekarská 53, Brno 656 91, Czech Republic. vladimir.vasku@fnusa.cz
Archives of Dermatological Research
|April 11, 2009
Summary
This study found a specific matrix metalloproteinase-2 (MMP-2) gene variant is less common in psoriasis patients with a family history of psoriasis, diabetes, and personal allergy history, suggesting MMP-2 influences psoriasis risk in certain groups.
Area of Science:
- Genetics
- Dermatology
- Molecular Biology
Background:
- Matrix metalloproteinase-2 (MMP-2) expression is elevated in psoriasis.
- Genetic variations in MMP-2 may influence psoriasis susceptibility and phenotypes.
- Psoriasis is linked to the 16q chromosome region, including the MMP-2 gene (PSORS8).
Purpose of the Study:
- To investigate the association between DNA polymorphic variants in the MMP-2 promoter gene and psoriasis.
- To explore the relationship between MMP-2 gene variants and psoriasis phenotypes, including comorbid heredity.
- To identify potential genetic modulators of psoriasis in specific patient subgroups.
Main Methods:
- Genotyping of four MMP-2 promoter polymorphisms (-1575G/A, -1306C/T, -790T/G, -735C/T) using PCR.
- Analysis of 582 Czech Caucasian individuals (386 psoriasis patients, 196 controls).
- Statistical association testing for case-control differences and genotype frequencies in relation to clinical data.
Main Results:
- A significant association was found between the GG genotype of the -790 MMP-2 polymorphism and psoriasis (Pcorr = 0.04).
- The GGCCTT genotype in the MMP-2 promoter was significantly less frequent in patients with a family history of psoriasis, diabetes, and personal history of allergy (Pcorr = 0.01).
- This GGCCTT genotype was also less common in psoriatic patients with a combined family history of psoriasis and diabetes, alongside personal allergy history (Pcorr = 0.04).
Conclusions:
- The GGCCTT genotype in the MMP-2 promoter may act as a protective factor against psoriasis in individuals with specific hereditary and personal risk factors.
- MMP-2, located in the PSORS8 region, is suggested as a gene modulator influencing psoriasis risk in particular subgroups.
- These findings contribute to understanding psoriasis genetic predisposition and may inform future pharmacogenetic-based therapy improvements.
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