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Achilles tendon ossification after treatment with acitretin
Markus Wuenschel1, Per Trobisch
1Orthopaedic Surgery, University of Tuebingen, Tuebingen, Germany.
The Journal of Dermatological Treatment
|April 11, 2009
Summary
Severe Achilles tendon ossification occurred in a patient treated with acitretin for lichen ruber. While pain resolved after stopping acitretin, the ossification was permanent, highlighting risks of retinoid therapy.
Area of Science:
- Dermatology
- Orthopedics
- Pharmacology
Background:
- Achilles tendon ossifications are uncommon, typically resulting from trauma or surgery.
- Retinoid therapies, like acitretin, are used for various dermatological conditions.
- Understanding drug-induced musculoskeletal side effects is crucial for patient safety.
Observation:
- A case report details a 10 cm Achilles tendon ossification in a patient undergoing acitretin treatment for lichen ruber.
- The ossification developed within months of initiating acitretin therapy.
- The patient experienced significant pain associated with the ossification.
Findings:
- Discontinuation of acitretin led to pain regression.
- The Achilles tendon ossification itself was irreversible despite treatment cessation.
- This suggests a potential link between acitretin use and severe tendon calcification.
Implications:
- This case highlights a rare but severe adverse effect of retinoid therapy, specifically acitretin.
- Healthcare providers should be vigilant for musculoskeletal complications during retinoid treatment.
- Further research may be warranted to elucidate the mechanism of acitretin-induced ossification and explore preventative strategies.
