Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 24, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists
11:23

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

Optimizing circuit design using a remote-mounted perfusion system.

Bradley Kulat1, Neale Zingle

  • 1Children's Memorial Hospital, Chicago, Illinois 60614, USA. bkulat@childrensmemorial.org

The Journal of Extra-Corporeal Technology
|April 14, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perfusionist Manpower Survey.

The journal of extra-corporeal technology·2019
Same author

A 2015-2016 Survey of American Board of Cardiovascular Perfusion Certified Clinical Perfusionists: Perfusion Profile and Clinical Trends.

The journal of extra-corporeal technology·2017
Same author

Successful Bridge to Transplant Using the TandemHeart(R) Left Ventricular Assist Device in a Pediatric Patient.

World journal for pediatric & congenital heart surgery·2013
Same journal

Corrigendum to: High pressure excursion in a radial design oxygenator.

The journal of extra-corporeal technology·2026
Same journal

Understanding pressure excursions in extracorporeal technologies: The role of shear stress and hematologic predisposition.

The journal of extra-corporeal technology·2026
Same journal

Toward standardized guidelines for distal perfusion cannulae in V-A ECMO and ECPELLA: timing, sizing, monitoring, and management.

The journal of extra-corporeal technology·2026
Same journal

Ventricular assist device simulation to improve staff confidence and knowledge when caring for patients supported with the Berlin heart☆.

The journal of extra-corporeal technology·2026
Same journal

Strategic decision-making for redo cardiac surgical patients with biventricular heart failure - description of a surgical technique.

The journal of extra-corporeal technology·2026
Same journal

Learning from a pitfall: Atrial septostomy in LV failure under VA-ECMO for pulmonary hypertension.

The journal of extra-corporeal technology·2026
See all related articles

A remote-mounted perfusion system significantly reduced cardiopulmonary bypass (CPB) blood use and priming volumes in cardiac surgery. This modification minimizes patient exposure to banked blood, enhancing safety and outcomes.

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Anesthesiology

Background:

  • Banked blood exposure during cardiac surgery is associated with adverse outcomes.
  • Minimizing blood exposure is a key goal, often achieved by reducing heart-lung machine priming volumes.
  • Previous strategies focused on modifying heart-lung machine components to decrease hemodilution and the need for banked blood.

Purpose of the Study:

  • To evaluate the impact of a remote-mounted perfusion system on priming volumes and banked blood usage during cardiopulmonary bypass (CPB).
  • To compare blood use and priming volumes before and after implementing a remote-mounted system.
  • To assess the effectiveness of this modification in reducing patient exposure to banked blood.

Main Methods:

  • Utilized Terumo's System 1 Advanced Heart-Lung machine with remotely mounted pump heads.

More Related Videos

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
08:32

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion

Published on: June 27, 2018

Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts
06:22

Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts

Published on: June 14, 2024

Related Experiment Videos

Last Updated: Jun 24, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists
11:23

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
08:32

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion

Published on: June 27, 2018

Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts
06:22

Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts

Published on: June 14, 2024

  • Minimized excess tubing length by positioning components closer to the patient and oxygenator.
  • Compared CPB blood use and priming volumes in four weight classes before and after system modification, using identical disposables and protocols.

    • Main Results:

    • Significant reductions in priming volumes were observed across all weight classes (e.g., 8-12 kg: 751.2 to 360.4 mL; 41+ kg: 1306.3 to 875.5 mL).
    • Substantial decreases in banked blood usage were recorded (e.g., 8-12 kg: 1.84 to 1.10 units; 41+ kg: 1.62 to 0.42 units).
    • Reductions were consistent across all pediatric weight categories studied.

    Conclusions:

    • Implementing a remote-mounted perfusion system effectively reduces priming volumes in cardiac surgery.
    • This system modification significantly decreases the requirement for banked blood administration during CPB.
    • The reduction in banked blood use translates to less patient exposure to allogeneic blood products, improving safety.