Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Assessment of iron availability using stable 54Fe.

J P Kaltwasser1, C Hansen, Y Oebike

  • 1Zentrum der Inneren Medizin, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

European Journal of Clinical Investigation
|August 1, 1991
PubMed
Summary

This study assessed oral iron bioavailability for treating iron deficiency anemia using 54Fe. Both iron preparations showed similar efficacy in boosting hemoglobin and ferritin levels, despite differing plasma iron responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The benefits and societal importance of pig welfare in slaughterhouses a narrative review.

Meat science·2025
Same author

The Magnetic Search Coil (MSC) on the TRACERS Mission.

Space science reviews·2025
Same author

Low latency optical-based mode tracking with machine learning deployed on FPGAs on a tokamak.

The Review of scientific instruments·2024
Same author

Tangential extreme ultraviolet and soft x-ray diagnostic system for time-resolved temperature measurement on the High Beta Tokamak-Extended Pulse.

The Review of scientific instruments·2023
Same author

Assistance dogs help reduce mental health symptoms among Australian Defence Force veterans and emergency services personnel: A pilot study.

Psychiatry research·2023
Same author

Feasibility study of a high spatial and time resolution beam emission spectroscopy diagnostic for localized density fluctuation measurements in Lithium Tokamak eXperiment-β (LTX-β).

The Review of scientific instruments·2022

Area of Science:

  • Biochemistry
  • Hematology
  • Nutritional Science

Background:

  • Iron deficiency anemia is a global health concern, necessitating effective oral iron supplementation.
  • Accurate assessment of iron bioavailability and therapeutic efficacy is crucial for optimizing treatment strategies.

Purpose of the Study:

  • To quantitatively assay the bioavailability of orally administered iron for hemoglobin synthesis.
  • To compare the efficacy of two iron preparations with different release rates in an induced iron deficiency model.

Main Methods:

  • Utilized a non-radioactive tracer (54Fe) to measure erythrocyte utilization and assess intestinal iron absorption.
  • Induced experimental iron deficiency in 18 healthy male volunteers via weekly phlebotomy.
  • Monitored hemoglobin, serum ferritin, and plasma iron tolerance curves over three months.

Related Experiment Videos

Main Results:

  • Mean iron utilization was comparable between the two preparations (23% vs. 22%).
  • Both preparations demonstrated similar average daily increases in hemoglobin (1.5 g/L) and serum ferritin levels.
  • Significant differences were observed in plasma iron tolerance curves, but not in overall therapeutic efficacy.

Conclusions:

  • Plasma iron tolerance curves alone are insufficient for comparing the therapeutic value of oral iron preparations.
  • Both tested iron preparations are equally effective in promoting hemoglobin synthesis and improving iron status.