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Updated: Jun 24, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Asymmetric synthesis of (-)-swainsonine
Yong-Shou Tian1, Jae-Eun Joo, Bae-Soo Kong
1College of Pharmacy, Sung Kyun Kwan University, Suwon 440-746, Korea.
Abstract:
We report a new asymmetric synthetic method for (-)-swainsonine utilizing a chiral oxazoline precursor. The key features in this strategy are the diastereoselective oxazoline formation reaction catalyzed by palladium(0), diasteroselective dihydroxylation, and the stereocontrolled allylation reaction with TiCl(4).
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