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Lymphangioleiomyomatosis: a case report.

Jill A Borovansky¹, Helene R Labonte, Erika S Boroff

¹Division of Community Internal Medicine, Mayo Clinic, Scottsdale, Arizona 85259, USA. borovansky.jill@mayo.edu

Journal of Women'S Health (2002)

|April 14, 2009

Summary

Lymphangioleiomyomatosis (LAM) is a rare lung disease. This case highlights LAM in a postmenopausal woman, emphasizing the need for broader clinical awareness and prompt diagnosis.

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Area of Science:

Pulmonology
Oncology
Rare Diseases

Background:

Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease.
Typically affects women of reproductive age, characterized by atypical smooth muscle cell proliferation.
Often leads to respiratory failure and is fatal without lung transplantation.

Observation:

Presents a case of a 51-year-old postmenopausal woman with hemoptysis.
Initial chest radiograph was unremarkable.
Computed tomography (CT) revealed characteristic pulmonary cysts.

Findings:

Diagnosis confirmed by HMB-45-positive lymphangiomyoma biopsy.
Highlights hemoptysis as a presenting symptom of LAM.
Suggests LAM may be underdiagnosed, even in postmenopausal women.

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Implications:

Underscores the importance of recognizing LAM beyond its typical demographic.
Emphasizes the need for primary care providers to consider LAM in differential diagnoses.
Promotes timely referral to specialized centers for improved patient outcomes.