Paroxysmal bipedal activity during syncope related to carotid body tumor

Involuntary patterned motor activity may occur during seizures, especially those of frontal lobe origin, and during transient ischemic attacks. Paroxysmal patterned motor activity in frontal lobe epilepsy has been attributed to direct involvement of mesial frontal regions by the epileptic discharge. Paroxysmal bipedal frenetic activity occurred during an episode of syncope in a patient with a carotid body tumor. The presence of rhythmic motor patterns similar to the epileptic ones also during syncope and cerebral ischemia suggest a phenomenon of release from neocortical inactivation, probably of innate motor behaviors generated by neural networks referred to as central pattern generators (CPGs).