Gastric outlet obstruction by Brunner's gland hyperplasia in an 8-year-old child

Ikbel El Faleh1, Nicolas Lutz, Maria-Chiara Osterheld

  • 1Department of Gastroenterology and Clinical Nutrition, University Hospital Lausanne, 1011 Lausanne, Switzerland.

Insights

Brunner's gland hyperplasia is rare in children, causing gastric outlet obstruction. This report details the youngest case, emphasizing histopathology and treatment options for this rare pediatric condition.

Area of Science:

  • Gastroenterology
  • Pediatric Surgery
  • Surgical Pathology

Background:

  • Brunner's gland hyperplasia (BGH) is a rare duodenal submucosal gland condition.
  • While documented in adults causing bleeding or obstruction, pediatric cases are exceptionally rare, with only two prior reports linked to chronic renal failure.

Observation:

  • This study presents the third pediatric case and the youngest reported instance of gastric outlet obstruction attributed to BGH.
  • The case highlights the critical need to consider BGH in pediatric patients presenting with upper gastrointestinal obstruction.

Findings:

  • Histopathological examination confirmed BGH as the cause of obstruction.
  • The report focuses on the specific histopathologic features and discusses available treatment strategies.

Implications:

  • This case expands the understanding of BGH in the pediatric population, particularly its association with gastric outlet obstruction.
  • It underscores the importance of accurate diagnosis and tailored treatment for BGH in young patients, even in the absence of chronic renal failure.

Related Concept Videos

Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...