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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

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[Depression in multiple sclerosis].

C Lebrun1, M Cohen

  • 1Service de neurologie, Hôpital Pasteur, Nice. lebrun-frenay.c@chu-nice.fr

Revue Neurologique
|April 14, 2009
PubMed
Summary
This summary is machine-generated.

Depression affects over half of multiple sclerosis (MS) patients, often early in the disease. MS patients respond well to treatments like psychotherapy and antidepressants, highlighting the need for regular mood monitoring.

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Area of Science:

  • Neurology
  • Psychiatry

Context:

  • Mood disturbances and depression are highly prevalent in multiple sclerosis (MS).
  • Depression in MS occurs more frequently than in age-matched populations or other chronic illnesses.
  • Depression can manifest early in the MS disease course and is linked to fatigue and cognitive impairment.

Purpose:

  • To summarize the prevalence and characteristics of depression in multiple sclerosis patients.
  • To emphasize the importance of screening for and monitoring depression in MS management.
  • To highlight treatment efficacy for depression in MS.

Summary:

  • Over 50% of multiple sclerosis patients experience depression, which is not directly linked to specific brain lesions but associated with other MS symptoms.
  • The risk of suicide appears elevated in MS patients.
  • Immunomodulatory treatments do not impact depression, underscoring the need for consistent mood assessment in all MS patients.

Impact:

  • Integrates depression screening and monitoring into routine multiple sclerosis care.
  • Informs clinicians that MS patients respond effectively to standard depression treatments, including psychotherapy and antidepressants.
  • Addresses a significant unmet need in the comprehensive management of multiple sclerosis, improving patient outcomes and quality of life.