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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R)
Masahiko Ito1, Toshihiro Sakamoto, Takao Suzuki
1Department of Metabolic Disorder, Tsukuba Research Institute, BANYU Pharmaceutical Co., Ltd, Okubo, Ibaraki, Japan. masahiko_ito2@merck.com
Bioorganic & Medicinal Chemistry Letters
|April 14, 2009
Abstract:
We have developed and characterized [(35)S]4a as a potent and selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R). Compound [(35)S]4a showed appreciable specific signals in brain slices prepared from wild-type mice but not from MCH1R deficient mice, confirming the specificity and utility of [(35)S]4a as a selective MCH1R radioligand for ex vivo receptor occupancy assays.
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