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Published on: April 19, 2011
The effect of xenon on isoflurane protection against experimental myocardial infarction
Jan H Baumert1, Marc Hein, Christina Gerets
1Department of Anesthesiology, University Clinic, Aachen, Germany. jan.baumert@googlemail.com
Objectives:
To investigate if the protective effects of xenon and isoflurane against myocardial ischemia-reperfusion damage would be additive.
Design:
A prospective, randomized laboratory investigation.
Setting:
An animal laboratory of a university hospital.
Participants:
Thirty-six pigs (female German landrace).
Interventions:
In an open-chest preparation with thiopental anesthesia, the left anterior descending artery was occluded to produce ischemia for 60 minutes. One hour previously, ischemic preconditioning, isoflurane (0.55 minimum alveolar concentration [MAC]) alone, or isoflurane together with xenon (0.55 MAC each) were started in the respective groups. A fourth (control) group received no protective intervention. Myocardial ischemia was followed by 2 hours of reperfusion.
Measurements And Main Results:
Hearts were excised and stained (Evans Blue/TTC) to measure infarct size as related to the area at risk. Myocardial infarct size was reduced (means +/- standard deviation) from 64% +/- 9% of the area at risk in the control group to 19% +/- 12% with ischemic preconditioning to 46% +/- 12% with isoflurane and to 39% +/- 13% with isoflurane and xenon. All intervention groups were significantly different from the control (p < 0.05), and both anesthetic groups were significantly different from ischemic preconditioning (p < 0.05).
Conclusion:
Combined isoflurane/xenon anesthesia reduced infarct size but not more than isoflurane alone. Ischemic preconditioning was more effective than the anesthetics.