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Related Concept Videos

Properties of Organometallic Compounds01:23

Properties of Organometallic Compounds

Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.
Ladder Diagrams: Complexation Equilibria01:07

Ladder Diagrams: Complexation Equilibria

Ladder diagrams are useful for evaluating equilibria involving metal-ligand complexes. The vertical scale of the ladder diagram represents the concentration of unreacted or free ligand, pL. The horizontal lines on the scale depict the log of stepwise formation constants for metal-ligand complexes and indicate the dominant species in all the regions.
The formation constant, K1, for the formation of Cd(NH3)2+ complex from cadmium and ammonia is 3.55 × 102. Log K1 (i.e. pNH3) is 2.55, and...
The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information about...
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...

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Related Experiment Video

Updated: Jun 24, 2026

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
09:33

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

Published on: December 17, 2018

Cadmium--a metallohormone?

Celia Byrne1, Shailaja D Divekar, Geoffrey B Storchan

  • 1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.

Toxicology and Applied Pharmacology
|April 14, 2009
PubMed
Summary
This summary is machine-generated.

Cadmium, a widespread environmental contaminant, acts as a potent metallohormone, mimicking steroid hormones. This review explores its mechanisms and potential role in hormone-dependent cancers.

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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
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Last Updated: Jun 24, 2026

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
09:33

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

Published on: December 17, 2018

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

Area of Science:

  • Environmental Science
  • Toxicology
  • Endocrinology

Background:

  • Cadmium is a prevalent environmental contaminant due to industrial use and byproduct generation.
  • Human exposure occurs through diet, smoking, and drinking water.
  • Cadmium has no known physiological function but exhibits hormonal activity.

Purpose of the Study:

  • To review evidence of cadmium mimicking steroid hormone function.
  • To elucidate the mechanisms of cadmium's hormonal activity.
  • To discuss cadmium's potential role in hormone-dependent cancers.

Main Methods:

  • Literature review of existing scientific evidence.
  • Analysis of studies on cadmium's interaction with hormone receptors.
  • Synthesis of data on cadmium's toxicological and endocrine effects.

Main Results:

  • Growing evidence indicates cadmium mimics steroid hormone functions.
  • Mechanisms involve interaction with hormone signaling pathways.
  • Potential links to the development of hormone-dependent cancers are suggested.

Conclusions:

  • Cadmium acts as a potent metallohormone.
  • Understanding its mechanisms is crucial for assessing health risks.
  • Further research is needed on its role in cancer development.