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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging
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Cell labeling and tracking for experimental models using magnetic resonance imaging.

Uwe Himmelreich1, Tom Dresselaers

  • 1Biomedical NMR Unit/Molecular Small Animal Imaging Center, Department of Radiology, Katholieke Universiteit Leuven, Onderwijs en Narvorsing 1, Herestraat 49, Bus 505, B-3000 Leuven, Belgium. uwe.himmelreich@med.kuleuven.be

Methods (San Diego, Calif.)
|April 14, 2009
PubMed
Summary

Magnetic Resonance Imaging (MRI) offers high-resolution in vivo cell tracking for cell-based therapies. This review covers MRI contrast agents, cell labeling, and spectroscopic methods for visualizing cellular processes, highlighting potential and challenges.

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Area of Science:

  • Biomedical Imaging
  • Cellular Biology
  • Molecular Imaging

Background:

  • Magnetic Resonance Imaging (MRI) is a powerful clinical diagnostic tool.
  • MRI is increasingly used for molecular and cellular imaging, offering high-resolution in vivo visualization.
  • Cellular imaging is crucial for cell-based therapies, requiring tracking of cell location and function.

Purpose of the Study:

  • To provide an overview of contrast generation strategies for MRI of cells.
  • To discuss various cell labeling and MRI methods for in vivo cell tracking.
  • To evaluate the potential, challenges, and shortcomings of MRI for visualizing cellular processes.

Main Methods:

  • Review of MR contrast agents and their application in cell imaging.
  • Exploration of diverse cell labeling techniques for MRI.
  • Analysis of MR spectroscopic methods for in vivo cell tracking.

Main Results:

  • MRI enables non-invasive monitoring of cell location and temporal changes with high anatomical detail.
  • Responsive contrast agents and MR imaging reporter gene expression expand MRI applications to functional cell investigations.
  • Various labeling approaches and methods offer distinct advantages and disadvantages for MRI-based cell tracking.

Conclusions:

  • MRI is a valuable technique for in vivo cell monitoring and tracking, crucial for advancing cell-based therapies.
  • Further development is needed to overcome challenges and fully realize MRI's potential in visualizing cellular processes.
  • Understanding the strengths and limitations of different MRI strategies is key for successful application in cellular imaging.