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Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents
Charles Francavilla1, Eddy Low, Satheesh Nair
1NovaBay Pharmaceuticals Inc., Emeryville, CA 94608, United States.
Bioorganic & Medicinal Chemistry Letters
|April 14, 2009
Summary
Researchers synthesized new analogs of a topical antimicrobial agent. This led to the discovery of quaternary ammonium N,N-dichloroamines as a novel class of topical antimicrobials with promising activity.
Area of Science:
- Medicinal Chemistry
- Antimicrobial Agents
- Organic Synthesis
Background:
- Topical antimicrobial agents are crucial for combating infections.
- Development of novel antimicrobial classes is essential due to rising resistance.
- Previous work focused on a specific clinical candidate (iii).
Purpose of the Study:
- To synthesize backbone modified and sulfonic acid replacement analogs of clinical candidate (iii).
- To evaluate the antimicrobial activity and aqueous stability of these novel compounds.
- To identify new classes of topical antimicrobial agents.
Main Methods:
- Synthesis of modified analogs.
- Antimicrobial activity assays.
- Aqueous stability testing at pH 4 and pH 7.
Main Results:
- Successful synthesis of various analogs.
- Identification of quaternary ammonium N,N-dichloroamines.
- Demonstrated antimicrobial activities and stability profiles.
Conclusions:
- Quaternary ammonium N,N-dichloroamines represent a new class of topical antimicrobial agents.
- These compounds show potential for further development in treating topical infections.
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