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POMC gene expression in mouse and hamster melanoma cells
1Department of Immunology and Microbiology, Albany Medical College, NY 12202.
FEBS Letters
|October 21, 1991
Abstract:
Expression of mRNA hybridizable to murine POMC cDNA, and immunoreactivity specific for POMC derived peptide, beta-endorphin, are reported for the first time in one murine and two hamster melanoma lines. The apparent sizes of POMC mRNA transcript were 3.5, 1.5 and 1 kb. It is suggested that POMC gene expression may be involved in the autoregulation of the melanoma phenotype at the cellular and tissue levels.