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Related Concept Videos

Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
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Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

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Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
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Peptic Ulcer01:27

Peptic Ulcer

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Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the...
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Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
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Peptic Ulcer Disease I: Introduction01:25

Peptic Ulcer Disease I: Introduction

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Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...
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Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

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Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant...
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Multidrug-resistant tuberculosis control in Rwanda overcomes a successful clone that causes most disease over a quarter century.

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Mycobacterium ulcerans Population Genomics To Inform on the Spread of Buruli Ulcer across Central Africa.

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Improving clinical and epidemiological predictors of Buruli ulcer.

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Subcutaneous Granulomatous Inflammation due to Basidiobolomycosis: Case Reports of 3 Patients in Buruli Ulcer Endemic Areas in Benin.

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Diagnostic Accuracy of Clinical and Microbiological Signs in Patients With Skin Lesions Resembling Buruli Ulcer in an Endemic Region.

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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
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Buruli ulcer.

Françoise Portaels1, Manuel T Silva, Wayne M Meyers

  • 1Mycobacteriology Unit, Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerpen, Belgium. kjanssens@itg.be

Clinics in Dermatology
|April 14, 2009
PubMed
Summary

Buruli ulcer, caused by Mycobacterium ulcerans, is a neglected tropical disease. This review covers its distribution, transmission, diagnosis, and treatment, highlighting its status as an emerging health concern.

Area of Science:

  • Infectious Diseases
  • Mycobacteriology
  • Public Health

Background:

  • Buruli ulcer is an indolent necrotizing disease caused by Mycobacterium ulcerans.
  • It is the third most common mycobacterial disease globally, following tuberculosis and leprosy.
  • Increasing recognition as an emerging health problem due to disabling and stigmatizing complications.

Purpose of the Study:

  • To provide a comprehensive overview of Buruli ulcer.
  • To discuss key aspects including epidemiology, pathogenesis, diagnosis, and treatment.
  • To raise awareness of Buruli ulcer as a significant public health issue.

Main Methods:

  • Literature review of existing studies on Buruli ulcer.
  • Synthesis of information on geographic distribution, incidence, and prevalence.

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  • Compilation of data on transmission, pathogenesis, immunity, clinical features, diagnosis, and treatment.

    • Main Results:

    • The review details the global geographic distribution and epidemiological data (incidence, prevalence).
    • Pathogenesis, immunity, and transmission routes of Mycobacterium ulcerans are discussed.
    • Clinical manifestations, diagnostic methods, differential diagnoses, and current treatment strategies are outlined.

    Conclusions:

    • Buruli ulcer requires increased attention from public health programs.
    • Understanding its multifaceted aspects is crucial for effective control and management.
    • Further research and integrated public health strategies are needed to combat this emerging disease.