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Published on: February 9, 2021

Cyclooxygenase inhibitors differentially modulate p73 isoforms in neuroblastoma

L M S Lau1, J K Wolter, J T M L Lau

  • 1Hospital for Sick Children, University of Toronto, Ontario, Canada.

Oncogene
|April 14, 2009
PubMed
Summary

Cyclooxygenase (COX) inhibitors promote cancer cell death by increasing proapoptotic TAp73 and decreasing antiapoptotic DeltaNp73 isoforms. These findings support COX inhibitors as potential cancer therapeutics, especially for tumors with deregulated E2F1.

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