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Updated: Jun 24, 2026

Comprehensive Understanding of Inactivity-Induced Gait Alteration in Rodents
Published on: July 6, 2022
Inactive lifestyle in adults with bilateral spastic cerebral palsy
Channah Nieuwenhuijsen1, Wilma M A van der Slot, Anita Beelen
1Department of Rehabilitation Medicine, Erasmus Medical Center, PO Box 2040, NL-3000CA Rotterdam, The Netherlands. c.nieuwenhuijsen@erasmusmc.nl
Objective:
To quantify the level of everyday physical activity in adults with bilateral spastic cerebral palsy, and to study associations with personal and cerebral palsy-related characteristics.
Participants And Methods:
Fifty-six adults with bilateral spastic cerebral palsy (mean age 36.4 (standard deviation (SD) 5.8) years, 62% male) participated in the study. Approximately 75% had high gross motor functioning. Level of everyday physical activity was measured with an accelerometry-based Activity Monitor and was characterized by: (i) duration of dynamic activities (composite measure, percentage of 24 h); (ii) intensity of activity (motility, in gravitational acceleration (g)); and (iii) number of periods of continuous dynamic activity. Outcomes in adults with cerebral palsy were compared with those for able-bodied age-mates.
Results:
Duration of dynamic activities was 8.1 (SD 3.7) % (116 min per day), and intensity of activity was 0.020 (SD 0.007) g; both outcomes were significantly lower compared with able-bodied age-mates. Of adults with cerebral palsy, 39% had at least one period of continuous dynamic activities lasting longer than 10 min per day. Gross motor functioning was significantly associated with level of everyday physical activity (Rs -0.34 to -0.48; p = 0.01).
Conclusion:
Adults with bilateral spastic cerebral palsy, especially those with low-level gross motor functioning, are at risk for an inactive lifestyle.
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