Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Ankle Joint01:10

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
Knee Joint01:23

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physician-expert Insights on the Variable Costs of Delayed Diagnoses Across 6 Conditions.

Journal of patient safety·2026
Same author

A miR-200b-Filamin A axis drives epicardial contribution to cardiogenesis.

Scientific reports·2026
Same author

[The journal "Der Schmerz"-40th anniversary].

Schmerz (Berlin, Germany)·2026
Same author

Efficacy and safety of eltrombopag in combination with dexamethasone as first-line treatment in adult patients with newly diagnosed immune thrombocytopenia.

British journal of haematology·2026
Same author

High pretreatment peripheral blood T-cell receptor clonality as a predictor of prolonged response in immune thrombocytopenia.

British journal of haematology·2026
Same author

Sympathosensory interactions - Possible relevance in osteoarthritis.

Osteoarthritis and cartilage·2025

Related Experiment Video

Updated: Jun 24, 2026

Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats
08:09

Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats

Published on: May 20, 2020

Joint pain.

Hans-Georg Schaible1, Frank Richter, Andrea Ebersberger

  • 1Institute of Physiology 1/Neurophysiology, University Hospital Jena, Teichgraben 8, 07740 Jena, Germany. Hans-Georg.Schaible@mti.uni-jena.de

Experimental Brain Research
|April 14, 2009
PubMed
Summary

Joint diseases cause chronic pain through inflammation and degeneration. This study explores pain mechanisms, focusing on mechanical hyperalgesia in inflammatory and osteoarthritic joint pain.

More Related Videos

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

Related Experiment Videos

Last Updated: Jun 24, 2026

Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats
08:09

Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats

Published on: May 20, 2020

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

Area of Science:

  • Neuroscience
  • Rheumatology
  • Pain Research

Background:

  • Chronic joint pain stems from inflammatory and degenerative diseases.
  • Osteoarthritic pain origins are less clear than inflammatory pain.
  • Mechanical hyperalgesia is a significant issue in both conditions.

Purpose of the Study:

  • To review the clinical problem of joint pain.
  • To elucidate mechanisms of peripheral and central sensitization in joint inflammation.
  • To examine long-term changes in chronic joint pain models.

Main Methods:

  • Review of existing literature on joint pain and nociception.
  • Analysis of molecular mechanisms of sensitization in joint nociceptors.
  • Examination of central sensitization pathways involving neurotransmitters and prostaglandins.

Main Results:

  • Joint nociceptors and spinal neurons exhibit heightened sensitivity to mechanical stimuli.
  • Cytokines play a key role in peripheral sensitization.
  • Excitatory amino acids, neuropeptides, and prostaglandins are implicated in central sensitization.

Conclusions:

  • Understanding sensitization mechanisms is crucial for managing chronic joint pain.
  • Further research into long-term changes in animal models can inform clinical strategies.
  • Targeting molecular pathways may offer new therapeutic avenues for joint pain.