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Gastric cancer in the era of molecularly targeted agents: current drug development strategies

Hendrik-Tobias Arkenau1

  • 1The Medical Professorial Unit, Prince of Wales Medical School, University of New South Wales, Level 1, South Wing, Edmund Blacket Building, Avoca Street, Sydney, NSW, 2031, Australia. ht.arkenau@unsw.edu.au

Journal of Cancer Research and Clinical Oncology
|April 14, 2009
PubMed

Insights

Gastric cancer remains a leading cause of cancer death globally. This review highlights new molecularly targeted agents and pathways for treating advanced gastric and gastroesophageal junction (GEJ) cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gastroenterology

Background:

  • Gastric cancer is a leading cause of cancer mortality worldwide, with poor survival rates for advanced stages.
  • Current treatments for advanced gastric and gastroesophageal junction (GEJ) cancers have limited efficacy.
  • Understanding cancer-specific molecular events has paved the way for novel therapeutic strategies.

Purpose of the Study:

  • To review recent advancements in targeting molecular pathways crucial for gastric cancer and GEJ cancer.
  • To provide an overview of emerging molecularly targeted agents and their mechanisms of action.

Main Methods:

  • Literature review of recent studies on molecular pathways in gastric cancer.
  • Analysis of targeted agents and their downstream signaling pathways.
  • Focus on epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), and others.

Main Results:

  • Identification of key molecular targets including EGFR, VEGFR, IGFR, c-Met, and the Akt-PI3k-mTOR pathway.
  • Development of targeted agents offers new therapeutic avenues for gastric and GEJ cancers.
  • Targeting these pathways shows promise in improving clinical outcomes.

Conclusions:

  • Molecularly targeted agents represent a significant advancement in gastric cancer therapy.
  • Targeting specific pathways offers a more personalized approach to treating advanced gastric and GEJ cancers.
  • Continued research into these pathways is essential for improving patient survival rates.

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