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Updated: Jun 24, 2026
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
[Drug permeability through buccal mucosa].
1Department of Pharmacy, Zhejiang University City College, Hangzhou 310015 China.
Summary
Drug permeability through the buccal mucosa is significantly higher than through human skin. This study investigated physicochemical properties influencing drug absorption via the buccal route.
Area of Science:
- Pharmacology
- Drug Delivery
- Biomaterials Science
Context:
- Buccal drug delivery offers an alternative route for systemic administration.
- Understanding drug permeation across the buccal mucosa is crucial for optimizing drug formulations.
- The buccal mucosa presents unique physicochemical barriers compared to other absorption sites.
Purpose:
- To investigate the impact of drug physicochemical properties on buccal mucosa permeability.
- To quantify drug permeability coefficients for model compounds across isolated porcine buccal mucosa.
- To compare buccal mucosa permeability with that of human skin.
Summary:
- Benzoic acid, caffeine, and hydrocortisone were used as model drugs to assess buccal permeability.
- Permeability coefficients were determined using isolated porcine buccal mucosa.
- Results demonstrated significantly higher permeability for these drugs through the buccal mucosa compared to human skin.
Impact:
- Findings suggest the buccal mucosa is a highly permeable barrier for drug absorption.
- Highlights the potential of buccal drug delivery systems for enhanced therapeutic outcomes.
- Provides valuable data for the rational design of buccal drug formulations.
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