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06:32
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
[Osteitis as a complication of BCG vaccination]
Akira Koyama1, Ichiro Toida, Shizuko Nakata
1Japan BCG Laboratory, 3-1-5, Matsuyama, Kiyose-shi, Tokyo 204-0022, Japan. koyama@bcg.gr.jp
Kekkaku : [Tuberculosis]
|April 15, 2009
Summary
Osteitis following Bacillus Calmette-Guérin (BCG) vaccination is rare, with an incidence of 0.2 per 100,000. Early diagnosis and treatment with chemotherapy are effective, leading to favorable outcomes in most cases.
Area of Science:
- Pediatrics
- Infectious Diseases
- Vaccinology
Context:
- Osteitis is a rare but serious complication following Bacillus Calmette-Guérin (BCG) vaccination.
- Understanding its incidence, clinical presentation, and diagnostic challenges is crucial for pediatric healthcare.
Purpose:
- To investigate the incidence, clinical features, diagnostic methods, and treatment outcomes of osteitis after BCG vaccination in Japanese children.
- To assess any increasing tendency of BCG osteitis and its relationship with vaccination timing.
Summary:
- The study reviewed 22 cases of BCG osteitis in Japanese children, finding a low incidence (0.2/100,000) with no increasing trend. Extremities were commonly affected, with diagnosis confirmed by BCG detection. Multiplex PCR and QFT are emerging diagnostic tools.
- Treatment with isoniazid (INH) and rifampicin (RFP) was highly effective, with most patients cured within 6-12 months. Immunodeficiency, particularly partial interferon-gamma receptor 1 deficiency, was noted in cases with multiple lesions.
Impact:
- BCG osteitis, though infrequent, necessitates clinical consideration. Prompt diagnosis and treatment are vital to prevent long-term bone defects and joint mobility issues.
- This research highlights the importance of continued surveillance and the effectiveness of current treatment protocols for BCG-related osteitis.
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