Related Experiment Video
Updated: Jun 24, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
Skin and environmental contamination with methicillin-resistant Staphylococcus aureus among carriers identified
Shelley Chang1, Ajay K Sethi, Brittany C Eckstein
1Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Abstract:
In a prospective study involving 115 patients with methicillin-resistant Staphylococcus aureus nares carriage, we found that skin and environmental contamination with methicillin-resistant S. aureus was as likely among individuals whose S. aureus carriage was identified only through active surveillance as it was among those individuals whose S. aureus carriage was identified clinically, which suggests that strategies to limit transmission must address colonized patients, as well as infected patients.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage can lead to skin and environmental contamination. Strategies to limit MRSA transmission should target both colonized and infected patients.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of healthcare-associated infections.
- Nasal carriage of MRSA is a major risk factor for subsequent infection and transmission.
Purpose of the Study:
- To compare the extent of skin and environmental contamination by MRSA in patients with clinically identified carriage versus those identified through active surveillance.
- To inform strategies for MRSA transmission control.
Main Methods:
- Prospective study design.
- Involved 115 patients with MRSA nares carriage.
- Assessed skin and environmental contamination in relation to MRSA carriage identification method (clinical vs. active surveillance).
Main Results:
- Skin and environmental contamination with MRSA was equally likely in patients with carriage identified clinically and those identified via active surveillance.
- This indicates that asymptomatic or subclinically colonized individuals contribute to MRSA spread.
Conclusions:
- MRSA transmission control strategies must encompass patients identified through active surveillance, not solely those with clinical MRSA identification.
- Addressing colonized individuals is crucial for comprehensive MRSA infection prevention.
Related Concept Videos
Staphylococcal Skin Infections
Clinical Significance of Antibiotic Resistance
Mechanism of Antibiotic Resistance in MRSA
Rapid Identification of Pathogens
The Skin Microbiota