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Published on: June 22, 2016
CD4+Foxp3+ T-regulatory cells in noninfectious uveitis
Steven Yeh1, Zhuqing Li, Farzin Forooghian
1Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|April 15, 2009
Summary
T-regulatory cells, crucial for immune balance, are reduced in active uveitis. Severe depletion in some patients suggests this loss is a key feature of severe uveitis.
Area of Science:
- Immunology
- Ophthalmology
Background:
- Uveitis is an inflammatory eye condition.
- T-regulatory cells play a vital role in immune system regulation.
Purpose of the Study:
- To evaluate CD4(+)Foxp3(+) T-regulatory cell populations in uveitis patients.
- To determine if T-regulatory cells correlate with uveitis disease features.
Main Methods:
- Flow cytometry was used to assess CD4(+)Foxp3(+) T-regulatory cells in 20 uveitis patients.
- Disease activity, diagnoses, and cystoid macular edema were reviewed.
- Real-time PCR assessed Foxp3 mRNA in two patients with very low T-regulatory cells.
Main Results:
- CD4(+)Foxp3(+) T-regulatory cell percentages were lower in active uveitis compared to inactive uveitis (P< .05).
- No significant differences were found in other subgroups.
- Two patients with recalcitrant uveitis and <1% CD4(+)Foxp3(+) cells had minimal or no Foxp3 mRNA.
Conclusions:
- T-regulatory cells are reduced in active uveitis.
- Severe depletion of CD4(+)Foxp3(+) T cells and Foxp3 mRNA in some patients indicates a potential role in severe uveitis pathogenesis.
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