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Updated: Jun 24, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
Published on: May 3, 2018
Association between cerebral arterial calcification and brachial-ankle pulse wave velocity in patients with acute
Kwang-Yeol Park1, Yong Bum Kim, Heui-Soo Moon
1Department of Neurology, Chung-Ang University Medical Center, Chung-Ang University College of Medicine, Seoul, South Korea.
Insights
Increased arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), is closely linked to cerebral arterial calcification in stroke patients. This suggests calcification severity reflects overall arterial stiffness.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Radiology
Background:
- Vascular calcification correlates with cardiovascular mortality.
- Arterial stiffness, assessed by pulse wave velocity, is linked to cardiovascular risk factors.
Purpose of the Study:
- To investigate the relationship between arterial stiffness and cerebral arterial calcification.
Main Methods:
- Brachial-ankle pulse wave velocity (baPWV) measured arterial stiffness.
- Cerebral arterial calcification assessed via CT angiography.
- Sixty-seven acute ischemic stroke patients without renal or peripheral arterial disease analyzed.
Main Results:
- A significant positive correlation found between baPWV and cerebral arterial calcification (r=0.524, p<0.001).
- Age also correlated significantly with baPWV (r=0.452, p<0.001).
- Age and cerebral arterial calcification independently determined baPWV.
Conclusions:
- Elevated baPWV is strongly associated with the extent of cerebral arterial calcification in acute ischemic stroke patients.
- Cerebral arterial calcification severity may represent systemic arterial stiffness.
Background/Aims:
Vascular calcification is known to be associated with cardiovascular mortality, and arterial stiffness measured by pulse wave velocity is associated with major cardiovascular risk factors. The aim of the present study was to elucidate the correlation between arterial stiffness and cerebral arterial calcification.
Methods:
Arterial stiffness, as measured by brachial-ankle pulse wave velocity (baPWV), and cerebral arterial calcification, as measured by CT angiography using a 40-multidetector scanner, were examined in patients with acute ischemic stroke. Sixty-seven subjects who were free of renal disease or peripheral arterial disease were included in the analysis.
Results:
Univariate analysis revealed that baPWV was significantly correlated with cerebral arterial calcification (r = 0.524, p < 0.001) and age (r = 0.452, p < 0.001), and multiple linear regression analysis indicated that age and cerebral arterial calcification were independent determinants of baPWV.
Conclusion:
We report that increased baPWV is closely associated with the degree of cerebral arterial calcification in patients with acute ischemic stroke. Our results suggest that the severity of cerebral arterial calcification is representative of the degree of systemic arterial stiffness.
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