Association between cerebral arterial calcification and brachial-ankle pulse wave velocity in patients with acute

Kwang-Yeol Park1, Yong Bum Kim, Heui-Soo Moon

  • 1Department of Neurology, Chung-Ang University Medical Center, Chung-Ang University College of Medicine, Seoul, South Korea.

European Neurology
|April 15, 2009
PubMed

Insights

Increased arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), is closely linked to cerebral arterial calcification in stroke patients. This suggests calcification severity reflects overall arterial stiffness.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Radiology

Background:

  • Vascular calcification correlates with cardiovascular mortality.
  • Arterial stiffness, assessed by pulse wave velocity, is linked to cardiovascular risk factors.

Purpose of the Study:

  • To investigate the relationship between arterial stiffness and cerebral arterial calcification.

Main Methods:

  • Brachial-ankle pulse wave velocity (baPWV) measured arterial stiffness.
  • Cerebral arterial calcification assessed via CT angiography.
  • Sixty-seven acute ischemic stroke patients without renal or peripheral arterial disease analyzed.

Main Results:

  • A significant positive correlation found between baPWV and cerebral arterial calcification (r=0.524, p<0.001).
  • Age also correlated significantly with baPWV (r=0.452, p<0.001).
  • Age and cerebral arterial calcification independently determined baPWV.

Conclusions:

  • Elevated baPWV is strongly associated with the extent of cerebral arterial calcification in acute ischemic stroke patients.
  • Cerebral arterial calcification severity may represent systemic arterial stiffness.
Abstract

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