[Novel methodological approaches to the evaluation of the immune status in sickly children with ENT organ pathology]

Principles of a novel methodology for the combined assessment of the immune function in sickly children with pathological changes in the organs of the otorhinolaringological system are expounded. The new approach includes investigations into local cellular and humoral immunity, evaluation of functional relationships and correlations between its parameters, interpretation of these findings, and the use of the characteristics thus obtained in the development of concrete recommendations for immunotropic and/or anti-inflammatory therapy. This approach is illustrated by examples of variations in the number of CD4(+) and CD20(+) cells and interplay between them. These findings taken together with the data on the levels of serum IgG, IgA, IgM, and percentage of immunohistochemical preparations positive for these immunoglobulins indicate that the proposed method may prove useful for the development of new therapeutic modalities for the treatment of sickly children with ENT organ pathology following adenotomy and tonsilotomy.