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Updated: Jun 24, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
Published on: May 6, 2019
Immunogenic and tolerogenic cell death
Douglas R Green1, Thomas Ferguson, Laurence Zitvogel
1Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. e-mails: douglas.green@stjude.org
Abstract:
The immune system is routinely exposed to dead cells during normal cell turnover, injury and infection. Mechanisms must exist to discriminate between different forms of cell death to correctly eliminate pathogens and promote healing while avoiding responses to self, which can result in autoimmunity. However, an effective immune response against host tissue is often needed to eliminate tumours following treatment with chemotherapeutic agents that trigger tumour cell death. Consequently, a central problem in immunology is to understand how the immune system determines whether cell death is immunogenic, tolerogenic or 'silent'.
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