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Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
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Related Experiment Video

Updated: Jun 24, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Delusions in frontotemporal lobar degeneration.

Rohani Omar1, Elizabeth L Sampson, Clement T Loy

  • 1Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.

Journal of Neurology
|April 15, 2009
PubMed
Summary

Delusions are a significant and early feature in frontotemporal lobar degeneration (FTLD), affecting an estimated 14% of patients. Paranoid and somatic delusions were most common in this young-onset dementia subtype.

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Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Frontotemporal lobar degeneration (FTLD) is a key cause of early-onset dementia.
  • Neuropsychiatric symptoms in FTLD are significant but not fully understood.
  • Delusions represent a specific neuropsychiatric feature requiring characterization.

Observation:

  • A retrospective review identified 8 patients with delusions among FTLD cases.
  • Delusions were present in an estimated 14% of the FTLD cohort.
  • Detailed clinical, neuropsychological, and MRI data were collected.

Findings:

  • Delusions appeared early, were prominent, and persistent in affected patients.
  • Paranoid and somatic delusions were the most common types observed.
  • Behavioural variant FTLD was the most associated subtype, often with right-sided or bilateral atrophy.

Implications:

  • Delusions represent a notable clinical manifestation in FTLD.
  • Further research is warranted to explore the role of delusions in FTLD.
  • Recognition of delusions can aid in the diagnosis and management of FTLD.