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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
Cytologic features of hydatidiform mole: a case report
Heejeong Lee1, Jeana Kim, Kyo Young Lee
1Department of Pathology, The Catholic University of Korea, Seoul, South Korea. heejung@catholic.ac.kr
Acta Cytologica
|April 16, 2009
Summary
Diagnosing hydatidiform mole in cervical cytology is rare. This case highlights identifying trophoblastic cells in cervical samples for accurate diagnosis, aiding early detection of this rare gynecologic condition.
Area of Science:
- Gynecologic Pathology
- Cytopathology
Background:
- Hydatidiform mole typically presents in the uterus.
- Cervical cytologic manifestation of hydatidiform mole is exceptionally rare.
Observation:
- A 52-year-old woman presented with heavy vaginal bleeding and a cervical mass.
- Initial cervical cytology was misdiagnosed as squamous cell carcinoma due to pleomorphic cells and obscuring blood.
- Ultrasound revealed a vascular uterine/cervical mass with cystic areas.
Findings:
- Histologic examination confirmed a partial hydatidiform mole involving the cervix.
- Careful cytologic review identified three trophoblastic cell types, including syncytiotrophoblastic cells.
- Accurate diagnosis of cervical hydatidiform mole was achieved using cytology and clinical data.
Implications:
- This case establishes the first report of hydatidiform mole in a cervical cytologic specimen.
- Highlights the importance of meticulous cytologic analysis for rare gynecologic diagnoses.
- Emphasizes the potential for cervical cytology to aid in diagnosing uterine pathologies.
