Related Experiment Videos
[Central corneal thickness, intraocular pressure and their correlation in healthy Czech children aged 7-17 years]
J Osmera1, A Filous, M Hlozánek
1Ocní klinika detí a dospelých UK 2. LF a FN Motol, Praha. jakub.osmera@email.cz
Insights
Normal central corneal thickness (CCT) and intraocular pressure (IOP) in healthy children aged 7-17 are similar to adults. A slight positive correlation exists between CCT and IOP, but it has minimal clinical significance.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Corneal Physiology
Context:
- Establishing normative data for ocular parameters in pediatric populations is crucial for accurate diagnosis and management.
- Previous studies have focused on adult populations, leaving a gap in understanding age-specific variations in children.
- Central corneal thickness (CCT) and intraocular pressure (IOP) are key indicators of ocular health, particularly for glaucoma screening.
Purpose:
- To prospectively determine normal central corneal thickness (CCT) and intraocular pressure (IOP) in healthy white children aged 7-17 years.
- To analyze the correlation of CCT and IOP with age and gender in this pediatric cohort.
- To investigate the relationship between CCT and IOP in healthy children.
Summary:
- This study assessed CCT and IOP in 124 healthy children (7-17 years). Mean CCT was 554 ± 33 µm, unaffected by age or gender. Mean IOP was 14.5 ± 2.6 mm Hg, with girls showing slightly higher IOP than boys (p=0.03).
- No significant influence of age on IOP was observed within the 7-17 year range.
- A positive correlation was found between CCT and IOP, with a 1.55 mm Hg change in IOP for every 100 µm change in CCT, deemed of minimal clinical importance.
Impact:
- Provides essential normative data for CCT and IOP in a pediatric population, aiding in the diagnosis of ocular conditions.
- Highlights that pediatric CCT and IOP values are comparable to adult ranges, simplifying clinical interpretation.
- The identified correlation between CCT and IOP, though statistically significant, suggests limited clinical utility for routine pediatric eye exams.
Unlabelled:
The purpose of this prospective study was to determine normal central corneal thickness (CCT) and intraocular pressure (IOP) in healthy white children aged 7-17 years and to analyze their possible correlation to age and gender. Further, the possible correlations between CCT and IOP were analyzed.
Methods:
CCT and IOP were assessed in 248 eyes of 124 healthy children aged 7-17 years (mean, 12.7 years). Fifty-four boys and 70 girls were included into the study. Further, the analyzed cohort was divided into subgroups of younger (7-12.4 years) and older (12.5-17 years) boys and girls. The data obtained from the whole cohort were statistically analyzed to assess normal CCT and IOP in healthy youth. Relation of CCT and IOP to age and gender, as well as relation between CCT and IOP were studied. The CCT was measured using ultrasonic pachymetry and IOP by means of Goldmann applanation tonometry.
Results:
The mean CCT +/- SD in 124 children was 554 +/- 33 microm (range, 437-641 microm); no influence of age or gender was detected. The mean IOP +/- SD in the whole cohort was 14.5 +/- 2.6 mm Hg (range, 10-25 mm Hg). Statistically significant difference of 0.7 mm Hg was found between boys and girls, where the mean IOP was 14.1 +/- 2.3 mm Hg in boys and 14.8 +/- 2.8 mm Hg in girls respectively (p = 0.03). Age had no influence on IOP for the age range of 7-17 years (p = 0.67). The positive correlation between CCT and IOP was found. The calculated correction was 1.55 mm Hg change of IOP for 100 microm change of CCT.
Conclusion:
CCT and IOP values in healthy children aged 7-17 years are similar to values in adults. The positive correlation between both parameters seems to be of minimal clinical importance.